The effects of UV exposure and aging are becoming an increasingly critical issue in clinical practice. Sun exposure and other sources of UV radiation play a major role in the early appearance of fine and coarse wrinkles, roughness, laxity, irregular pigmentation, and roughness of the skin. This clinical guide is the first of its kind to describe the vast array of treatment options available for the minimization and repair of the effects of photodamage—prompting clinicians to tailor therapeutic regimens to individual components of aging and balance the risks and benefits of each treatment against patient expectations.