On the eve of Mary Sue Prescott's forty-fifth birthday, four childhood friends -- The Girlfriends' Club -- gather at a lakeside cabin. It's a bittersweet celebration as Mary Sue is scheduled for a mastectomy in the morning. When Mary Sue's boyfriend finally shows up, she has already gone to bed. Drunk and angry, he trips, breaks his neck, and dies. Horrified, the three other women put him in his car and send it careening into the lake.

How these women deal with their awful secret parallels their lives and relationships to this point. Pamela is at the beck and call of her rich and boorish husband. Gretchen gave up a promising career to marry an adulterous man who eventually left her for his secretary. Dixie -- also divorced -- is involved in an extended long-distance affair with a handsome but married vineyard owner; as she plays the role of the dreaded "other woman, " even her closest friends can't know. And Mary Sue, the ebullient cheerleader, had lived an idyllic married life until she found her husband carrying on with a sexy widow. Shattered, she convinced herself to fall in love with a contentious and truculent drunk.

In addition to keeping their terrible secret, the women must continually deal with their ever-complicated lives and relationships. And it is these trials, and the struggle to find one's place in a world where everyone is younger and prettier that is at the heart of this moving and ultimately triumphant novel.